On this week’s episode of Fast Facts – Perio Edition, Katrina Sanders, we are continuing the conversation that we started last week in discussing periodontitis as a manifestation of systemic disease highlighting patients that present with Leukocyte Adhesion Deficiency Syndrome.
“When we talk about patients who have Leukocyte Adhesion Deficiency Syndrome, there’s a problem with the way these white blood cells actually adhere to that endothelium.”
“So if you see patients who are experiencing recurrent infection of periodontal disease, delayed wound healing, and sores in the area, it would behoove this patient to get testing done to identify if they’ve experienced any type of a genetic component or change in gene expression associated with Leukocyte Adhesion Deficiency Syndrome.”
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Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., … & Tonetti, M. S. (2018). Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, Geurs NC, Hughes FJ, Jin L, Kantarci A, Lalla E, Madianos PN, Matthews D, McGuire MK, Mills MP, Preshaw PM, Reynolds MA, Sculean A, Susin C, West NX, Yamazaki K. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun;89 Suppl 1:S237-S248. doi: 10.1002/JPER.17-0733. PMID: 29926943.