On this week’s episode of Fast Facts – Perio Edition, Katrina Sanders, we are continuing the conversation around periodontitis as a manifestation of systemic disease discussing patients that present with Infantile genetic agranulocytosis.
“You see, an individual who has Infantile genetic agranulocytosis is an individual who is born, present at birth with this congenital or genetic disorder. We also, by the way, can have individuals who experience acquired agranulocytosis.”
“We understand, of course, that these neutrophils, these white blood cells, are a really important component of the immune system because they aid in the fighting of infection. So if an individual has infantile genetic agranulocytosis, these are individuals who absolutely are going to be prone to infection.”
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Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., … & Tonetti, M. S. (2018). Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, Geurs NC, Hughes FJ, Jin L, Kantarci A, Lalla E, Madianos PN, Matthews D, McGuire MK, Mills MP, Preshaw PM, Reynolds MA, Sculean A, Susin C, West NX, Yamazaki K. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun;89 Suppl 1:S237-S248. doi: 10.1002/JPER.17-0733. PMID: 29926943.